Location: Cambridge, MA

Position Summary :

Reporting to the Head of Vector Engineering, the Senior Scientist will work with others in the Vector Engineering team to implement cutting-edge AAV technology to improve efficacy, potency, safety and production of rAAV vectors.

Responsibilities:

• Execute viral studies, both rAAV and Adenovirus, that drive the company's research and development goalsAssist with the design and construction of rAAV vectorsEstablish and manage relationships with external academic groups and CROs
• Coordinate in vivo experiments internally or directly with CROsWorking with the cell line isolation, process development and analytical development teams, implement small-scale rAAV production for yield and quality assessmentsPrepare, analyze, and present data internally and externall
• Prepare and review technical reports and write research operating protocols (ROPs)Work within cross-functional teams to drive novel programs forward towards INDe studies .
• RequirementsPhD in Virology, Cell Biology, Molecular Biology, Biochemistry, Chemical Engineering or a related discipline3 or more years of industry experience preferred .
• Experience in mammalian cell culture, molecular biology, protein biochemistry, immunoassays, flow cytometry, and quantitative PCR methods .
• Experience in the development of complex biological assaysExperience with statistical analysis software (SoftMax, JMP, SAS) preferred .
• Experience working with external contract labs (CMOs, CROs) is a plusStrong collaboration and team-working skillsStrong communication, interpersonal and organizational skillsProven ability to work independently and effectively plan and organize work activities and prioritize task completion to meet schedules and deadlines